Clophen:

CONTRAINDICATIONS & CAUTIONS
Special precautions should be observed in patients with enlarged ovaries. These women are thought to be more sensitive to this drug and should receive small doses. Any patient who complains of abdominal symptoms hould be carefully examined. The maximum ovarian enlargement occurs after the 5-days course has been completed and many patient can be shown to have a palpable increase in ovarian size by the seventh to tenth days.